Wilms Tumor Ppt New May 2026

  • Favorable vs. Anaplastic Histology:

    • A “new” PPT is incomplete without late effects.

    New survivorship care plan: All patients should have an electronic survivorship passport with lifetime recommendations. wilms tumor ppt new

  • Key genes: WT1 (11p13), WT2 (11p15), CTNNB1, AMER1.
  • Radiation-related:
  • Surgical: Chronic kidney disease (if bilateral or large resection).
  • Recommendations: Lifelong follow-up (cardiac, renal function, breast MRI for females after chest radiation).
  • Labs:
  • Tissue diagnosis: Biopsy not routine – diagnosis made by imaging + nephrectomy (except if bilateral or unresectable).

    • By following this structure, your Wilms Tumor PowerPoint will be clear, current, and clinically useful – whether for teaching or self-study. Favorable vs

  • Key Stat: Accounts for ~6% of all childhood cancers.

    • Out with “low/intermediate/high”? Not exactly – but refined. A “new” PPT is incomplete without late effects

    New COG/SIOP harmonized risk groups (AREN0534, UMBRELLA):

    | Risk Group | Criteria | Treatment | |------------|----------|------------| | Low | Stage I favorable histology, age <2y, tumor weight <550g | Nephrectomy only (no chemo) | | Standard | Most stage I-III favorable histology, no adverse molecular markers | Vincristine + actinomycin ± doxorubicin | | High | Diffuse anaplasia, stage IV favorable with blastemal type, TP53 mutation, 1q gain | Intensified chemo (regimen M) + radiation + consider experimental |

    New addition: Patients with unfavorable molecular signature (1q gain + 1p loss) are now automatically high-risk regardless of stage.