For the Collector: Yes. Physical copies of PCSE00608 are becoming rare. The NTSC release had a smaller print run than the Japanese version. A sealed copy is currently valued at $60-$90 USD.
For the Player who owns a PS Vita: Conditionally yes. You must install the 1.03 patch, and you really should overclock your Vita. If you play it stock, the slowdowns will frustrate you.
For the Modern Gamer: No. Play the PS4, PC, or Nintendo Switch versions instead. The Vita version is a technical curiosity, not the definitive experience. Resident Evil - Revelations 2 -PCSE00608- -NTSC-
For the Emulation Enthusiast: Waiting on Vita3K. Check compatibility lists for PCSE00608 specifically.
Yes, if:
No, if:
The NTSC cartridge (PCSE00608) requires Update Patch 1.03 (approx 800MB) to fix the following: For the Collector: Yes
Without the update, the game is borderline unplayable. With the update, it is solid.