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Fix: The resolution is set too high for your monitor. Delete VsFix.ini and let the game regenerate it. Start with 1920x1080.
The DODI Repack of MGS2: Substance is the most convenient way to play the PC port on modern systems. It’s pre-patched, lightweight, and installs quickly – ideal if you don't want to tinker with original disc images or PS2 emulation. metal gear solid 2 dodi repack
Fix: Dodi repacks require a lot of virtual memory. Increase your Windows Page File to at least 4GB. Also, ensure you are running setup.exe as Administrator. Fix: The resolution is set too high for your monitor