Libusb-win64-devel-filter-1.2.6.0.exe -

Cause: The older libusb 1.2.6.0 drivers may not be SHA-2 signed or cross-signed with newer certificates. Fix:

The package typically includes:

PyUSB relies on the system libusb DLL. After installing libusb-win64-devel-filter-1.2.6.0.exe, place libusb-1.0.dll in your system path or next to your Python script. Then: libusb-win64-devel-filter-1.2.6.0.exe

import usb.core
dev = usb.core.find(idVendor=0x1234, idProduct=0x5678)
dev.set_configuration()
# ... read/write endpoints ...