A: Only if your PS3 is backward compatible (CECHA/B/C/E models) and running custom firmware. You’d need to convert the ISO to an encrypted PS2 Classics format—more trouble than it’s worth.
Guitar Hero 2 is one of the easier PS2 games to emulate because it’s not 3D-heavy. Even a laptop with Intel HD Graphics can run it at 60 FPS if you: Guitar Hero 2 Ps2 Iso Highly Compressed
Guitar Hero II is best played with a guitar controller. A: Only if your PS3 is backward compatible
If you aren't playing on a physical PS2, you will likely use the PCSX2 emulator. Here are the recommended specs to run the game smoothly without audio lag: Guitar Hero II is best played with a guitar controller